Relationship of serum estradiol levels with age and lesion severity in women with knee osteoarthritis

doi:10.3969/j.issn.2095-4344.2014.46.030

Abstract

Abstract:

BACKGROUND: The pathogenesis of knee osteoarthritis is still not very clear, and there is a lack of early diagnosis methods. Because it is more common in middle-aged women, it is suggested that the pathogenesis of knee osteoarthritis may be closely related to serum estradiol levels in the human body.

OBJECTIVE: To explore the correlation between the level of serum estradiol and the severity of osteoarthritis in female patients with knee osteoarthritis.

METHODS: Seventy-six female patients with knee osteoarthritis admitted in the First Affiliated Hospital of Guangxi Medical University from February 2012 to December 2013 were enrolled, and divided into premenopause group (n=42) and postmenopause group (n=34). According to Kellgren-Lawrence (K-L) grading, both two groups were subdivided into K-L 0, II and IV groups. The knee function was evaluated with Hospital for Special Surgery (HSS) Knee Score Standard in USA, the serum estradiol levels were detected with electrochemiluminescence immunoassay. Then, the correlation analysis was performed.

RESULTS AND CONCLUSION: The serum estradiol levels of the premenopause group and postmenopause group were decreased significantly with the increase of K-L grade and age (P < 0.05). Under the same K-L grade, the serum estradiol levels in the postmenopausal patients were significantly lower than those in the premenopausal patients. Linear regression analysis showed that there was a negative relationship between age and serum estradiol level (R²=0.222, P < 0.05), and there was a positive correlation between HSS scores and serum estradiol levels (R²=0.415, P < 0.05). The severity of knee osteoarthritis in female patients shows a negative correlation with the level of serum estradiol but a positive correlation with age.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: menopause, estradiol, osteoarthritis, knee, estrogens

CLC Number:

R318

Liang Hai-bo, Su Wei, Luo Shi-xing. Relationship of serum estradiol levels with age and lesion severity in women with knee osteoarthritis [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(46): 7533-7537.

Figures/Tables 2

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